Empirical therapy advisor
Before culture results are back: how likely is each antibiotic to cover the pathogen of a patient like this one, in this ward, given the last 12 months of results and today's alerts.
Based on 50 first isolates · ICU · Bloodstream infection · 2025-03-16 → 2026-03-15
Intensive care unitNo single agent reaches 80 % coverage for this profile. Highest coverage without active warning:
ciprofloxacin 46 % (33 %–60 %)
Best two-drug combination: ciprofloxacin + vancomycin covers 90 % (79 %–96 %)
Take cultures before treatment; consider a combination and discuss with infectious
diseases if the patient is severely ill.
Not covered: Staphylococcus aureus (28 %), Enterococcus faecalis (16 %), Escherichia coli (6 %)
AntibioticCoverage, 12 months (95 % CI)12 mo4 wk
⚠ Active MRSA cluster (6 cases): β-lactams do not cover MRSA
56 %
20 %
n = 5
⚠ Active MRSA cluster (6 cases): β-lactams do not cover MRSA
52 %
20 %
n = 5
ceftriaxone CRO
trend · Escherichia coli ⚠ Active MRSA cluster (6 cases): β-lactams do not cover MRSA
46 %
20 %
n = 5
cefuroxime CXM
trend · Escherichia coli ⚠ Active MRSA cluster (6 cases): β-lactams do not cover MRSA
44 %
0 %
n = 5
ampicillin AMP
trend · Escherichia coli ⚠ Active MRSA cluster (6 cases): β-lactams do not cover MRSA
38 %
20 %
n = 5
⚠ Staphylococcus aureus: 50 % resistant in the last 4 weeks (baseline 6 %)
20 %
20 %
n = 5
ceftazidime CAZ
trend · Pseudomonas aeruginosa ⚠ Active MRSA cluster (6 cases): β-lactams do not cover MRSA
6 %
0 %
n = 5
mecillinam MEC
not for this site⚠ Active MRSA cluster (6 cases): β-lactams do not cover MRSA
0 %
0 %
n = 5
trimethoprim TMP
not for this site0 %
0 %
n = 5
nitrofurantoin NIT
not for this site0 %
0 %
n = 5
Most likely organisms for this profile
Escherichia coli
38 %
Staphylococcus aureus
28 %
Enterococcus faecalis
16 %
Klebsiella pneumoniae
6 %
Pseudomonas aeruginosa
6 %
Klebsiella oxytoca
4 %
Decision support only: coverage is the share of first isolates from similar patients that were susceptible (an organism not tested for a drug counts as not covered). It does not replace local treatment guidelines, allergy and severity assessment, or clinical judgement. The black tick on each bar is the coverage target; the bracket is the 95 % confidence interval.